- This disambiguation page lists articles associated with the same title. If an internal link led you here, you may wish to change the link to point directly to the intended article.
- Spike, the character from the TV shows Buffy the Vampire Slayer and Angel
- Spike, the dragon character from My Little Pony
- Mike "Spike" Scarlatti, the character from Flashpoint
- Spike Spiegel, the character from the anime Cowboy Bebop
- Spike Witwicky, the character from the Transformers franchise