- This disambiguation page lists articles associated with the same title. If an internal link led you here, you may wish to change the link to point directly to the intended article.
- a fundamental Starfleet law of noninterference. See Prime Directive at Memory Alpha for more Star Trek canon info.
- the Star Trek: TOS zine The Prime Directive, published by a Port Jefferson fan club
- the Star Trek: TOS zine Prime Directive, published by The Federation
- the Star Trek club newsletter Prime Directive, a newsletter published by a fan club in Bemidji, MN
- Prime Directive, a Star Trek club zine published by Trek Australis in Australia
- Prime Directive a Star Trek: TOS story by Karla Kelly, published in Scattered Stars #3